منابع مشابه
Neurophysiological endophenotypes across bipolar and schizophrenia psychosis.
The search for liability genes of the world's 2 major psychotic disorders, schizophrenia and bipolar disorder I (BP-I), has been extremely difficult even though evidence suggests that both are highly heritable. This difficulty is due to the complex and multifactorial nature of these disorders. They encompass several intermediate phenotypes, some overlapping across the 2 psychotic disorders that...
متن کاملPhenotyping psychosis: room for neurocomputational and content-dependent cognitive endophenotypes?
INTRODUCTION The endophenotype research strategy aims at reducing complex clinical phenomena to reveal a more tractable mapping to underlying genes. Cognitive dysfunctions have been widely pursued as target endophenotype in schizophrenia. We critically discuss the promise and limitations of this approach. METHODS Relevant theoretical and empirical issues on genes and behaviour, neurocognitive...
متن کاملDynamic endophenotypes and longitudinal trajectories: capturing changing aspects of development in early psychosis.
The search for replicable markers — biological, psycho logical, social or their combinations — for psychiatric ill nesses carries on. In psychosis, attention has been directed to atrisk and firstepisode populations, given the possibility that following markers in young people will avoid the con founds of chronicity and exposure to pharmacological treat ments. A variety of promising biomar...
متن کاملA polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains
This large multi-center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi-modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients with psychosis, 822 unaffected first-degree relatives of patients, and 2,333 controls. Endophenotypes included the P300 event-related potential (N = 515), lateral ventricular ...
متن کاملPsychosis following Tramadol Withdrawal
Abstract Background: Tramadol is a centrally acting opioid analgesic used to treat moderate to sever pain. It has more advantage and less opioid adverse effects than conventional opioid analgesia. Case Report: This article reports a patient with tramadol dependency that had psychosis after tramadol withdrawal. Conclusion: By the increase of tramadol usage for relief of chronic pain, t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of General Psychiatry
سال: 2008
ISSN: 1744-859X
DOI: 10.1186/1744-859x-7-s1-s55